The speed loop of the vector control of permanent magnet linear synchronous motor (PMLSM) was usually controlled by PI. The traditional PI controller has some shortcomings such as overshoot in the starting process and long adjusting time under load disturbance. In order to improve the servo performance, sliding mode control was applied to the servo system, but its shortcoming was buffeting. Therefore, a sliding mode control method based on endocrine hormone regulation was proposed, which could effectively reduce the overshoot of speed and shorten the adjusting time when the hormone was disturbed by external disturbance by using the ultra short feedback mechanism of hormone secretion. The simulation model of the system was built in MATLAB. The simulation results showed that the control performance of speed and thrust was remarkable and excellent, and was better than the traditional PI control and sliding mode control.