For the fault tolerance topology of neutral-point-clamped (NPC) three-level inverter and its control problem, considering the case of inverter power devices open-circuit fault and the change of space vector after the fault occurs, the fault-tolerant three-level inverter model is set up by connecting the output terminal to the neutral point of the DC link, so as to implement fault-tolerant control under open-circuit fault. At the same time, considering the neutral point voltage balance in the DC side of the inverter, zero sequence voltage injection method is adopted to suppress the fluctuation of neutral point potential. Simulation results show that the fault-tolerant control strategy is feasible and effective.