Magnetic bearing has many advantages such as no friction, no wear and no lubrication. It has broad application prospects in the fields of blower, compressor and heating ventilation air conditioning (HVAC). For a 65 kW, 30 000 r/min heat pump compressor, a 5-degree-of-freedom (5-DOF) active magnetic bearing is designed based on the requirements of maximum load capacity and rotor diameter limitation. Aiming at the modal resonance problem of heat pump compressor after cabinet installation, the resonance mode is suppressed and eliminated by increasing the support strength of mounting frame. The magnetic bearing has been successfully applied to the practical heat pump compressor. In all operation conditions, the sensitivity function value of the magnetic bearing system is less than 12 dB, and the maximum peak-to-peak value of the rotor vibration is no more than 80 μm, especially it is less than 20 μm in the working speed range. It means that the heat pump compressor with the magnetic bearing can run stably for a long time, meeting the ISO 14839 requirements.