In order to improve the dynamic response speed and robustness of permanent magnet linear synchronous motor (PMLSM) control system, a fixed-time integral sliding mode control (DFISMC) method based on disturbance estimation compensation was proposed. Firstly, based on the integral sliding mode surface, a sliding mode control algorithm with fixed-time was introduced to ensure that the system can reach the equilibrium point within a fixed-time. Secondly, a control rate gain function f(s) was designed to adjust dynamically with the state of the system, which further accelerates the convergence rate. Finally, an adaptive superspiral disturbance observer was designed to estimate the internal and external mismatched disturbances, and the observed values were introduced into the control rate by feedforward compensation, which enhances the antiinterference ability of the system. The simulation results show that the DFISMC method not only guarantees the global robustness of the system, but also improves the tracking accuracy and response speed of the system.