In order to solve the problem that induction machines generate time harmonics in the windings when supplied at variable frequency, which leads to the increase of electromagnetic vibration and noise, an improved sine pulse width modulation control strategy using hybrid harmonic injection is proposed. A 1 120 kW submersible induction machine is taken as the research object, by injecting 3rd and 9th hybrid harmonics into the machine, the modulation wave of voltage, carrier harmonics and their side harmonics components are weakened, thus reducing the vibration noise of the machine. The harmonic ratio coefficients in the 3rd and 9th hybrid harmonics injection methods are optimized to further strengthen the weakening of sideband harmonics and reduce the machine noise overall. Finally, by comparing the performance of the machine with hybrid harmonic injection method and the conventional machine before optimization in terms of iron consumption and copper consumption, it is verified that the proposed strategy effectively attenuates the electromagnetic noise of the machine without affecting the basic performance of the machine.